Systemic and organ involvement in monogenic autoinflammatory disorders: a global review filtered through internists’ lens

Monogenic autoinflammatory disorders (AIDs) are rare diseases driven by cytokine-mediated extraordinary sterile inflammation that results from the activation of innate immune pathways. The clinical hallmark of these diseases is the recurrence of stereotyped episodes of systemic- and organ-specific inflammation; the most common systems involved being the skin, musculoskeletal system, gastrointestinal tract, and central nervous system. The autoinflammatory disorders may have a profound impact on the quality of life of the affected patients, and a delayed diagnosis may lead to severe complications, the most dreadful of which is AA-Amyloidosis. This review gives an overview on the four main AIDs, namely familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrinopathies, and mevalonate kinase deficiency, focusing on their clinical phenotype in adults and differential diagnosis, suggesting a diagnostic algorithm, and reviewing the available treatments.     

Quality of Life Among Food Allergic Patients and Their Caregivers

Food allergy is increasing in prevalence worldwide. This review summarizes progress made studying relationships between food allergy and quality of life (QOL), with an emphasis on recent work in the field. Early work examining QOL among food allergy patients established that stress and anxiety associated with continuous allergen avoidance and the looming threat of anaphylaxis were associated with significantly impaired food allergy quality of life (FAQOL) for children with food allergy and their caregivers. Recent clinical studies suggest that undergoing oral food challenge to confirm food allergy and oral immunotherapy to treat food allergy may each improve FAQOL among both patients and their caregivers. Other intervention modalities, such as nurse-facilitated counseling and educational workshops, also hold promise, but additional work is needed. Future work must strive to recruit more representative, population-based samples, including adult patients, in order to improve the generalizability and clinical relevance of findings.     

Geschlechtsrollenentwicklung Jugendlicher

This article encompasses three central concepts: sex, development of roles and youth. It seems appropriate first to define the terms describing these concepts and to build the framework and context in which they will subsequently be used. Based on this, questions about gender role development of young people will be asked. These will be discussed in the context of psycho dramatic theory of development and illustrated through case vignettes. With regard to the psycho dramatic wording of the process of gender role development of youth, this paper primarily is of an explorative nature.     

Online Shopping Behavior Study Based on Multi-granularity Opinion Mining: China Versus America

With the development of e-commerce, many products are now being sold worldwide, and manufacturers are eager to obtain a better understanding of customer behavior in various regions. To achieve this goal, most previous efforts have focused mainly on questionnaires, which are time-consuming and costly. The tremendous volume of product reviews on e-commerce Web sites has seen a new trend emerge, whereby manufacturers attempt to understand user preferences by analyzing online reviews. Following this trend, this paper addresses the problem of studying customer behavior by exploiting recently developed opinion mining techniques. This work is novel for three reasons. First, questionnaire-based investigation is automatically enabled by employing algorithms for template-based question generation and opinion mining-based answer extraction. Using this system, manufacturers are able to obtain reports of customer behavior featuring a much larger sample size, more direct information, a higher degree of automation, and a lower cost. Second, international customer behavior study is made easier by integrating tools for multilingual opinion mining. Third, this is the first time an automatic questionnaire investigation has been conducted to compare customer behavior in China and America, where product reviews are written and read in Chinese and English, respectively. Our study on digital cameras, smartphones, and tablet computers yields three findings. First, Chinese customers follow the Doctrine of the Mean and often use euphemistic expressions, while American customers express their opinions more directly. Second, Chinese customers care more about general feelings, while American customers pay more attention to product details. Third, Chinese customers focus on external features, while American customers care more about the internal features of products.     

The Importance of Military Cultural Competence

Military cultural competence has recently gained national attention. Experts have posited that limited outcomes in the treatment of posttraumatic stress disorder and depression in the military may be related to limited familiarity with the military. National surveys have indicated low military cultural competence among providers and limited educational efforts on military culture or pertinent military pathology in medical schools and residency training programs. Military families, with their own unique military cultural identity, have been identified as a population with increased risks associated with deployment. In response to these findings, several curricula regarding military culture have been established and widely distributed. Assessments of military cultural competence have also been developed. The clinical impact of enhanced cultural competence in general has thus far been limited. The military, however, with its highly prescribed cultural identity, may be a model culture for further study.